Transcriptomics

Dataset Information

0

Effects of long-term endocrine disrupting compound exposure on Macaca mulatta embryonic stem cells


ABSTRACT: Endocrine disrupting chemicals (EDCs) exert significant effects on health and physiology, many of which are traceable to effects on stem cell programming underlying organismal development. Understanding risk of low-level, chronic EDC exposure will be enhanced by knowledge of effects on stem cells. We exposed rhesus monkey embryonic stem cells to low levels of five different EDCs for 28 days, and evaluated effects on gene expression by RNAseq transcriptome profiling. EDCs tested included bisphenol A (BPA), atrazine (ATR), tributyltin (TBT), perfluorooctanoic acid (PFOA), and di-(2-ethylhexyl) phthalate (DEHP). We observed little effect of BPA, and small numbers of affected genes (119 or fewer) with the other EDCs. There was substantial overlap in effects across two, three, or four treatments. Ingenuity Pathway analysis indicated suppression of cell survival genes, activation of cell death genes, suppression of genes downstream of several stress response mediators, and modulations in several genes that regulate pluripotency, differentiation, and germ layer development. Potential adverse effects of these changes on development are discussed.

ORGANISM(S): Macaca mulatta

PROVIDER: GSE86939 | GEO | 2016/09/15

SECONDARY ACCESSION(S): PRJNA343029

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2018-03-06 | GSE103033 | GEO
2019-09-01 | GSE119329 | GEO
2018-06-19 | GSE115946 | GEO
2016-09-01 | GSE86259 | GEO
2022-03-02 | GSE191199 | GEO
2011-11-04 | E-GEOD-33481 | biostudies-arrayexpress
2019-12-25 | GSE108499 | GEO
2011-11-04 | GSE33481 | GEO
2021-01-01 | E-MTAB-7576 | biostudies-arrayexpress
2024-01-01 | GSE207039 | GEO