Protein Kinase CK2 Controls the Fate Between Th17 Cell and Regulatory T Cell Differentiation
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ABSTRACT: We report that CK2 inhibition with CX-4945 broadly suppresses Th17-associated effector and metabolic gene expression. CD4+ T cells were cultured in IL-6, IL-23 and TGFb1 for 72 h, in the absence of presence of 2 mM CX-4945, RNA-seq was performed and gene expression compared between the control and treatment groups.
ORGANISM(S): Mus musculus
PROVIDER: GSE86976 | GEO | 2017/05/05
SECONDARY ACCESSION(S): PRJNA343123
REPOSITORIES: GEO
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