Transcriptomics

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Aurora B phosphorylates hnRNP U/SAF-A to facilitate XIST RNA removal from the inactive X chromosome during mitosis


ABSTRACT: We show that Aurora-B phosphorylates heterogeneous nuclear ribonucleoprotein U (hnRNP U) in the SAP domain to dissociate hnRNP U from chromatin during mitosis. We use RNA-seq to show that hnRNP U associates with hundreds of mRNAs and lncRNAs during interphase and mitosis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE87200 | GEO | 2020/09/02

REPOSITORIES: GEO

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