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Comparison of apoptosis related gene expression in p7-p14 mouse lenses

ABSTRACT: Lens development exhibits a seamless progression from embryogenesis through ageing. Lens maturation and growth proceed throughout life; lens fibre cells differentiate from lens epithelial cells at the equator of the lens, migrate inwards at the bow region and mature around pre-existing fibre cells at the centre of the lens. Lens fibre cells lose their nuclei via an apoptosis like mechanism as they mature. We therefore decided to study further the relationship of apoptosis related gene expression during vital stages of lens maturation in the mouse. This is an important question as defects in lens function and/or maturation result in clouding of the lens, or cataract, which can result in considerable visual impairment. Keywords: development/age comparison

ORGANISM(S): Mus musculus

PROVIDER: GSE8731 | GEO | 2007/08/11

SECONDARY ACCESSION(S): PRJNA101989

REPOSITORIES: GEO

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Expression data from lenses triply deficient for E2F1, E2F2, and E2F3 transcription factors

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