Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression of candidate genes in Celiac Disease - Regulatory elements and their targets (part 4)

ABSTRACT: Celiac disease is a chronic immune-mediated disorder with an important genetic component. We analyzed the expression of regulatory elements (4) and some of their targets in biopsies from duodenum.

ORGANISM(S): Homo sapiens

PROVIDER: GSE87460 | GEO | 2018/09/28

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Expression of candidate genes in Celiac Disease - Associated genes and regulatory elements (part 1)

Project description:Celiac disease is a chronic immune-mediated disorder with an important genetic component. We analyzed the expression of candidate genes and regulatory elements in biopsies from duodenum.

2018-09-28 | GSE87457 | GEO

Expression of candidate genes in Celiac Disease - Associated new genes and regulatory elements (part 2)

Project description:Celiac disease is a chronic immune-mediated disorder with an important genetic component. We analyzed the expression of candidate new genes and regulatory elements (2) in biopsies from duodenum.

2018-09-28 | GSE87458 | GEO

Expression of candidate genes in Celiac Disease - Associated new genes and regulatory elements (part 3)

Project description:Celiac disease is a chronic immune-mediated disorder with an important genetic component. We analyzed the expression of candidate new genes (2) and regulatory elements (3) in biopsies from duodenum.

2018-09-28 | GSE87459 | GEO

Analysis of expression of genes involved in celiac disease

Project description:Celiac disease (CD) is a chronic immune-mediated disorder with an important genetic component. We analyzed the expression of candidate genes in biopsies from duodenum.

2016-10-31 | GSE84729 | GEO

Transcriptomic Signature of Celiac show induced epithelial proliferation coupled with suppressed metabolic functions

Project description:Background and aims: Celiac disease is provoked by gluten exposure, but the resultant pathogenic process in the duodenum is not well understood. We aimed to define the core celiac transcriptomic signature and pathologic pathways in pre-treatment diagnostic duodenum biopsies. Methods: We use mRNAseq to define pre-treatment diagnostic duodenum gene expression in 54 pediatric celiac patients and non-celiac controls, and we validate our key findings in an independent cohort of 40 participants. We further define similar and divergent genes and pathways in 177 Crohn disease patients and controls. Results: We observe a marked suppression of mature epithelial metabolic functions in celiac patients, overlapping substantially with the Crohn signature. A marked adaptive immune response was noted for the up-regulated signature including interferon response, alpha-beta, and gamma-delta T-cells that overlapped to some extant with the Crohn signature. However, we identified a celiac specific signature linked to increased cell proliferation, nuclear division, and cell cycle activity that was localized primarily to the epithelia as noted by CCNB1 and Ki67 staining. Lastly, we demonstrate the utility of the transcriptomic date to correctly classify disease or healthy states in the discovery and validation cohorts. Conclusion: Our data provide insights into celiac pathogenesis and can stimulate new approaches to address this highly prevalent condition.

2020-04-10 | GSE131705 | GEO

Expression analysis in intestinal mucosa of genes under association peaks in celiac disease

2014-09-30 | GSE61849 | GEO

Expression analysis in intestinal mucosa of genes under association peaks in celiac disease

Project description:Celiac disease is a chronic immune-mediated disorder with an important genetic component. To date, there are 57 independent association signals from 39 non-HLA loci, and a total of 66 candidate genes have been proposed. We aimed to scrutinize the functional implication of 45 of those genes by analyzing their expression in the disease tissue of celiac patients (at diagnosis/treatment) compared to non-celiac controls. The sample set consisted of 15 CD children at diagnosis (on a gluten-containing diet, with CD associated antibodies, atrophy of intestinal villi and crypt hyperplasia), and the same patients in remission after being treated with GFD for >2 years (asymptomatic, antibody negative, and normalized intestinal epithelium at that time), plus 15 tissue samples from non-celiac individuals not suffering from inflammation at the time of endoscopy used as controls

2014-09-30 | E-GEOD-61849 | biostudies-arrayexpress

Human gut derived-organoids as model to study gluten response and effects of microbiota bioproducts in celiac disease

Project description:Celiac disease (CeD) is an intestinal immune-mediated disorder caused by gluten ingestion in genetically predisposed subjects. CeD is characterized by villous atrophy, altered intestinal permeability, crypt hyperplasia and innate and adaptive immune response. This study aimed to develop and validate the use of intestinal organoids from celiac patients to study CeD. A repository of organoids from duodenum of non-celiac and celiac patients was generated and characterized accordingly to standard procedures. RNA-seq analysis was employed to study the global gene expression program of CeD (n=3) and non-CeD (n=3) organoids sets. While the three celiac derived organoids shared similar transcriptional signatures the NC samples set appeared more heterogeneous. We found 486 genes differentially expressed between the two groups. Of them, 299 genes were downregulated (FC<2; FDR<0.05) and 187 were upregulated in CeD (FC >2; FDR<0.05). We observed CeD organoids had significantly altered expression of genes associated with barrier function, innate immunity, and stem cell function.

2019-05-29 | GSE113492 | GEO

Different gene expression signatures in children and adults with celiac disease

Project description:We collected 19 duodenal biopsies of children and adults with celiac disease and compared the expression of 38 selected genes between each other and with the observed in 13 non-celiac disease controls matched by age. qPCR gene expression profiling. Intestinal samples from children and adults with active celiac disease patients and controls were analysed.

2015-12-19 | E-GEOD-76168 | biostudies-arrayexpress

Different gene expression signatures in children and adults with celiac disease

2015-12-19 | GSE76168 | GEO