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Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE87884 | GEO | 2016/11/01

SECONDARY ACCESSION(S): PRJNA348101

REPOSITORIES: GEO

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Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate.

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Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate (part 1)

Project description:Recent studies have identified Zeb2 as a transcription factor important for the final maturation of natural killer cells and effector CD8+ T cells. We show that Zeb2 is required for the development of two myeloid cell types, the monocyte and the plasmacytoid dendritic cell, and clarify that this factor is not required for the development of classical dendritic cells.

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