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Differential gene expression in human valve interstitial cells of normal aortic valves and calcified aortic valves

ABSTRACT: Valve interstial cells(VICs) are the major cellular compents in the aortic valve. Under pathological circumstances, normal VICs differentiate into myofibroblasts or osteoblast-like phentotypes, which play important roles in the pathogenesis of calcified aortic valve disease. We used micrroarrary analysis to compare the global programme of gene expression in normal and calcified human aortic valve intersitial cells (VICs), in order to find out some key factors that mediate the phenotype change of VICs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE88803 | GEO | 2016/10/23

SECONDARY ACCESSION(S): PRJNA348688

REPOSITORIES: GEO

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