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Comparison of gene expression signatures between Cre- KTC organoid organoid and Cre+ KTC organoid

ABSTRACT: To identify downstream genes involved in cholangiocarcinoma development by genetic manipulations of Kras, TGFbR2, and CDH1, we cultured the biliary organoid from the extrahepatic bile duct of Cre-negative LSL-KrasG12D;Tgfbr2flox/flox;CDH1flox/flox (KTC) mice, and induced gene recombination using a lentivirus expressing Cre-recombinase (Cre+ KTC organoid) or control lentivirus (Cre- KTC organoid). Then, we compared gene expression signatures between Cre- KTC organoid organoid and Cre+ KTC organoid.

ORGANISM(S): Mus musculus

PROVIDER: GSE88900 | GEO | 2017/04/30

SECONDARY ACCESSION(S): PRJNA349041

REPOSITORIES: GEO

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