Transcriptomics

Dataset Information

0

Expression data from lung tumors of KrasTgfbr2 -/- mouse model


ABSTRACT: Recent data suggests that repression of the Type II TGF-B Receptor (Tgfr2) repression in human lung adenocarcinoma is important for progression from noninvasive to invasive adenocarcinoma. To test this hypothesis in a animal model of non-invasive lung cancer, we generated an inducible, lung specific Tgfbr2 knockout model in the oncogenic Kras mouse. LSL-KrasG12D positive mice were simultaneously backcrossed to C57/Bl6 mice and to the Tgfbr2 flox/flox mice. To induce tumors, 100 _l of saline containing 3x10e10 particles of an adenovirus containing the Cre recombinase (Ad.Cre) was administered to each LSL-KrasG12D mouse intra-nasally.

ORGANISM(S): Mus musculus

PROVIDER: GSE27717 | GEO | 2011/09/15

SECONDARY ACCESSION(S): PRJNA141803

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2011-09-15 | GSE27675 | GEO
2011-09-14 | E-GEOD-27717 | biostudies-arrayexpress
2011-09-14 | E-GEOD-27675 | biostudies-arrayexpress
2017-04-30 | GSE88900 | GEO
2016-06-30 | GSE81154 | GEO
2023-05-31 | GSE225083 | GEO
2020-08-10 | E-MTAB-9131 | biostudies-arrayexpress
2016-06-30 | E-GEOD-81154 | biostudies-arrayexpress
2019-06-30 | GSE132096 | GEO
2017-02-06 | GSE84448 | GEO