A Survey of Genetic Human Cortical Gene Expression

ABSTRACT: It is widely assumed that genetic differences in gene expression will underpin much of the differences between individuals and many of the quantitative traits of interest to geneticists. Despite this, there has been little work on genetic variability in human gene expression and almost none in the human brain. This is because the tools for assessing this genetic variability were not available. With whole genome SNP genotyping arrays and whole transcriptome expression arrays, these experiments have now become feasible. We have carried out whole genome genotyping and expression analysis on a series of 193 neuropathologically normal human brain samples using the Affymetrix GeneChip Human Mapping 500K Array Set and Illumina HumanRefseq-8 Expression BeadChip platforms. Here we present data showing that 58% of the transcriptome is cortically expressed in at least 5% of our samples, and of these cortically expressed transcripts 21% have expression profiles that correlate with their genotype. These genetic expression effects should be useful in determining the underlying biology of associations with common diseases of the human brain and in guiding the analysis of the genomic regions involved in the control of normal gene expression. Keywords: neuropathologically normal cortex

ORGANISM(S): Homo sapiens

PROVIDER: GSE8919 | GEO | 2007/11/04

SECONDARY ACCESSION(S): PRJNA102323

REPOSITORIES: GEO