Transcriptomics

Dataset Information

0

Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B


ABSTRACT: Resistance towards anti-angiogenic therapy (AAT) still represents a substantial clinical challenge. We report here that tumor-infiltrating mast cells (MC) are powerful mediators decreasing efficacy of AAT in mice and cancer patients. They act in a cell-extrinsic manner by secreting granzyme B, which liberates pro-angiogenic mediators from the extracellular matrix. In addition, MC also diminish efficacy of anti-angiogenic agents in a cell-autonomous way, which can be blocked by the mast cell degranulation inhibitor cromolyn. Our findings are relevant in humans because patients harboring higher numbers of MC in their tumors have an inferior outcome after anti-angiogenic treatment in the Gepar Quinto randomized Phase 3 clinical trial. Thus, MC-targeting might represent a novel promising approach to increase efficacy of AAT.

ORGANISM(S): Mus musculus

PROVIDER: GSE89395 | GEO | 2017/09/15

SECONDARY ACCESSION(S): PRJNA352051

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA352051 | ENA
2024-06-18 | PXD044140 | Pride
2009-12-31 | E-GEOD-18500 | biostudies-arrayexpress
2021-06-05 | GSE176149 | GEO
2015-12-22 | E-GEOD-76202 | biostudies-arrayexpress
2021-06-15 | E-MTAB-9227 | biostudies-arrayexpress
2024-10-03 | GSE224089 | GEO
2021-11-25 | PXD023851 | Pride
2022-08-24 | PXD030989 | Pride
2013-02-06 | E-GEOD-39382 | biostudies-arrayexpress