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Effect of TLR2 coactivation on Naïve CD4+ T cells differentiation and function

ABSTRACT: We have recently demonstrated that mycobacterial ligands engage Toll like receptor 2 (TLR2) on CD4+ T cells and up-regulate T-cell receptor (TCR) triggered- Th1 responses in vitro and in vivo. To extend our previous studies on the role of TLR2 in the regulation of T-cell function and differentiation, we compared the gene expression profile of mouse CD4+ T cells co-stimulated via CD28 or TLR2. Unlike CD28 co-stimulation, TLR2 co-engagement with CD3 triggered the regulation of a very discrete set of genes. Unexpectedly, naïve CD4+ T- cells co-stimulated via TLR2 showed a significant up-regulation of Il9 mRNA compared to cells co-stimulated via CD28.

ORGANISM(S): Mus musculus

PROVIDER: GSE89513 | GEO | 2017/08/04

SECONDARY ACCESSION(S): PRJNA352415

REPOSITORIES: GEO

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