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RNA-seq transcriptome analysis in naïve and TNF-a-treated Sirt6-silenced YAMC cells to enrich for direct Sirt6 targets associated with inflammatory stimulation.

ABSTRACT: By comparing Sirt6-silenced YAMC cells to siControl-transfected YAMC cells, we found that there were 916 and 1,026 differentially expressed genes in the naïve and TNF-a treatment conditions respectively. We also found that there were 302 genes that were co-expressed differentially in both naïve and TNF-a treatment conditions between Sirt6-silenced and siControl-transfected YAMC cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE89620 | GEO | 2018/01/03

SECONDARY ACCESSION(S): PRJNA352727

REPOSITORIES: GEO

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