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Transcriptomes of mouse N-Myc drived B-Acute-Lymphoblastic-Leukemia (B-ALL) leukemia cells treated with fasting

ABSTRACT: We reported that fasting completely inhibits the development of Acute Lymphoblastic Leukemia (ALL) in mouse models, by inducing a rapid differentiation and clearance of ALL cells. To determine the underlying mechanisms, we transplanted N-Myc expressed lineage negative (Lin-) fetal live cells with a GFP reporter into mice to initiate B-ALL development. At the middle stage of B-ALL development when GFP+% in PB reached about 60%, the B-ALL mice were fasted 1-day or 2-days. GFP+B220+ B-ALL cells from 1-day, 2-day fasted mice and control mice were collected by flow cytometry for RNA-seq analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE89622 | GEO | 2016/11/08

SECONDARY ACCESSION(S): PRJNA352730

REPOSITORIES: GEO

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