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Whole Genome Bisulfite sequencing for liver DNA methylation analysis of rat exposed to 0.05% Pb

ABSTRACT: We generated 4 Gb of high-quality sequencing data (~1 Gb per sample). The NCD+0.05%Pb group had hypermethylation at the whole genome level, compared to NCD. Difference analysis in gene methylation aimed at TSS region indicated that a total of 2733 genes experienced DNA methylation changes, with 2320 hypermethylated genes and 413 hypomethylated genes of the NCD+0.05%Pb group compared with the NCD group.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE89919 | GEO | 2016/11/17

SECONDARY ACCESSION(S): PRJNA354305

REPOSITORIES: GEO

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