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Mapping nucleolus-associated chromatin interactions by nucleolus-Hi-C reveals repression network

ABSTRACT: Nucleolus plays a key role in organizing global nuclear structure and facilitating gene regulation, but the three dimensional information within the nucleolus associated chromatins are still unknown, so here we development the Nucleolus Hi-C (NHi-C) experimental technique, which combines the nucleolus isolation with Hi-C experiment, and study the interactions within and surrounding nucleolus in human cells with a high resolution. With NHi-C experiment, we report how the nucleolus-associated chromatin regions interact at genome scale, and how these interactions organize the repressive nucleus architecture.

ORGANISM(S): Homo sapiens

PROVIDER: GSE90003 | GEO | 2021/02/01

SECONDARY ACCESSION(S): PRJNA354332

REPOSITORIES: GEO

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