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Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids Ib

ABSTRACT: We have mapped regulatory loci for nearly all protein coding genes in the mammalian genome using microarray measurements from a panel of mouse/hamster radiation hybrids. Keywords: regulation of gene expression

ORGANISM(S): Cricetulus griseus Mus musculus

PROVIDER: GSE9041 | GEO | 2008/03/13

SECONDARY ACCESSION(S): PRJNA105313

REPOSITORIES: GEO

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Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids Ia

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Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids II

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Mapping regulatory loci protein coding genes IN THE mouse genome USING microarray measurements FROM a panel OF mouse/hamster radiation hybrids (control I)

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Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids Ib

Project description:Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids Ib

| PRJNA105313 | ENA

Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids II

Project description:Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids II

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Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids Ia

Project description:Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids Ia

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Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids.

Project description:We mapped regulatory loci for nearly all protein-coding genes in mammals using comparative genomic hybridization and expression array measurements from a panel of mouse-hamster radiation hybrid cell lines. The large number of breaks in the mouse chromosomes and the dense genotyping of the panel allowed extremely sharp mapping of loci. As the regulatory loci result from extra gene dosage, we call them copy number expression quantitative trait loci, or ceQTLs. The -2log10P support interval for the ceQTLs was <150 kb, containing an average of <2-3 genes. We identified 29,769 trans ceQTLs with -log10P > 4, including 13 hotspots each regulating >100 genes in trans. Further, this work identifies 2,761 trans ceQTLs harboring no known genes, and provides evidence for a mode of gene expression autoregulation specific to the X chromosome.

| S-EPMC3014048 | biostudies-literature

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