Methylation profiling

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Sodium arsenite effects on DNA methylation in zebrafish embryos.


ABSTRACT: There is a need to develop biomarkers in alternative testing models predictive for chemically induced chronic disease in humans, preferably describing key events and their relationships in an adverse outcome pathway analysis. Epigenetic modifications, and particularly DNA methylation effects, have been implicated as a major event in susceptibility to develop chronic disease. Arsenic exposure affects large populations around the world through drinking water and industrial activities. We sought to identify epigenetic markers of arsenic exposure. We analyzed the effect of sodium arsenite on DNA methylation in Danio rerio (zebrafish) embryos using unbiased methylation profiling by high throughput sequencing.

ORGANISM(S): Danio rerio

PROVIDER: GSE90735 | GEO | 2017/10/19

SECONDARY ACCESSION(S): PRJNA355643

REPOSITORIES: GEO

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