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RNA-SEQ of mutants B cell for IgH 3'RR and Emu

ABSTRACT: RNA-SEQ of mutants B cell for IgH 3'RR and Emu

OTHER RELATED OMICS DATASETS IN: PRJNA355955PRJNA355956PRJNA355859

ORGANISM(S): Mus musculus

PROVIDER: GSE90758 | GEO | 2017/06/13

SECONDARY ACCESSION(S): PRJNA355956

REPOSITORIES: GEO

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SmallRNA-SEQ of mutants B cell for IgH 3'RR and Emu

Project description:SmallRNA-SEQ of mutants B cell for IgH 3'RR and Emu

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The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination

Project description:Class Switch Recombination (CSR) is a DNA recombination reaction that diversifies the effector component of antibody responses. CSR is initiated by activation-induced cytidine deaminase (AID), which targets transcriptionally active immunoglobulin heavy chain (Igh) switch donor and acceptor DNA. The 3’ Igh super-enhancer, 3’ Regulatory Region (3’RR), is essential for acceptor region transcription, but how this function is regulated is unknown. Here we identify the chromatin reader ZMYND8 as an essential regulator of the 3’RR and CSR. In B cells, ZMYND8 binds promoters and super-enhancers, including the 3’RR, and controls its activity by modulating the enhancer transcriptional status. In its absence, there is increased 3’RR polymerase loading, and decreased acceptor region transcription and CSR. In addition to CSR, ZMYND8 deficiency impairs somatic hypermutation (SHM) of Igh, which is also dependent on the 3’RR. Thus ZMYND8 controls Igh diversification in mature B lymphocytes by regulating the activity of the 3’ Igh super-enhancer.

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Mus musculus

Project description:SmallRNA-SEQ of mutants B cell for IgH 3'RR and Emu

| PRJNA355955 | ENA

Mus musculus

Project description:RNA-SEQ of mutants B cell for IgH 3'RR and Emu

| PRJNA355956 | ENA

Transcriptoma analysis of B splenocytes of 3'RR-deficient mice and wt mice

Project description:The IgH 3' regulatory region (3'RR) controls class switch recombination and somatic hypermutation in mice. Similar numbers of B cells are found in spleen of 3'RR-deficient mice and wt mice. We compare their transcriptoma in order to find differences in their maturation status.

2014-01-15 | GSE45230 | GEO

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