Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
DISEASE(S): Type 2 Diabetes Mellitus
SUBMITTER: mark Jedrychowski
LAB HEAD: Bruce Spiegelman
PROVIDER: PXD017424 | Pride | 2020-03-02
REPOSITORIES: pride
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Nature 20200219 7796
The sympathetic nervous system innervates peripheral organs to regulate their function and maintain homeostasis, whereas target cells also produce neurotrophic factors to promote sympathetic innervation<sup>1,2</sup>. The molecular basis of this bi-directional communication remains to be fully determined. Here we use thermogenic adipose tissue from mice as a model system to show that T cells, specifically γδ T cells, have a crucial role in promoting sympathetic innervation, at least in part by d ...[more]