Distinct Brca1 mutations differentially reduce hematopoietic stem cell function
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ABSTRACT: Mgbemena et al report that hematopoietic stem cells have an absolute requirement for Brca1 to survive. They also show that humanization of the mouse Brca1 e with a knocked-in BRCA1 cDNA, but not a mutant BRCA1/5382insC cDNA, fully substitutes for the mouse Brca1 during both embryonic development and hematopoiesis.
ORGANISM(S): Mus musculus
PROVIDER: GSE91390 | GEO | 2017/02/01
SECONDARY ACCESSION(S): PRJNA356889
REPOSITORIES: GEO
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