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Effects of XPC overexpression on global methylation

ABSTRACT: The study examines the impact of XPC overexpression on DNA demethylation in human dermal fibroblasts (HDFs) and during the early phase of somatic cell reprogramming (pre-iPSCs). We profiled the 5mC status in wild type and XPC gain-of-function HDFs and pre-iPSCs on a genome-wide scale by MeDIP-seq. XPC overexpression results in a loss of DNA methylation in both HDFs and pre-iPSCs. In XPC gain-of-function cells, not only does DNA methylation occur in fewer regions compared to control WT cells, but overall methylation levels are lower than in WT cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE92445 | GEO | 2017/05/22

SECONDARY ACCESSION(S): PRJNA357592

REPOSITORIES: GEO

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