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AMPK signaling for naïve pluripotency [Hs]

ABSTRACT: We show activation of AMP kinase (AMPK) with single chemical compounds can endow naïve pluripotency. AMPK activators reverted early-stage differentiating cells or epi-stem cells to naïve state. Moreover, AMPK activators reverted human ESCs to naïve state with pluripotent gene expression profiles and X-chromosome reactivation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE92725 | GEO | 2019/03/30

SECONDARY ACCESSION(S): PRJNA358469

REPOSITORIES: GEO

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AMPK signaling for naïve pluripotency [Mm]

Project description:We show activation of AMP kinase (AMPK) with single chemical compounds can endow naïve pluripotency. AMPK activators reverted early-stage differentiating cells or epi-stem cells to naïve state. Moreover, AMPK activators reverted human ESCs to naïve state with pluripotent gene expression profiles and X-chromosome reactivation.

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