Transcriptomics

Dataset Information

0

Transcriptomic, Proteomic, and Metabolomic Landscape of Positional Memory in the Caudal Fin of Zebrafish


ABSTRACT: Regeneration requires cells to regulate proliferation and patterning according to their spatial position. Positional memory is a property that enables regenerating cells to recall spatial information from the uninjured tissue. Positional memory is hypothesized to rely on gradients of molecules, few of which have been identified. Here, we quantified the global abundance of transcripts, proteins and metabolites along the proximodistal axis of caudal fins of uninjured and regenerating adult zebrafish. Using this approach, we uncovered complex overlapping expression patterns for hundreds of molecules involved in diverse cellular functions, including developmental and bioelectric signaling as well as amino acid and lipid metabolism. Moreover, 32 genes differentially expressed at the RNA level had concomitant differential expression of the encoded proteins. Thus, the identification of proximodistal differences in levels of RNAs, proteins, and metabolites will facilitate future functional studies of positional memory during appendage regeneration.

ORGANISM(S): Danio rerio

PROVIDER: GSE92760 | GEO | 2017/01/21

SECONDARY ACCESSION(S): PRJNA358533

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-07-22 | GSE272731 | GEO
2022-10-13 | E-MTAB-9676 | biostudies-arrayexpress
| PRJNA1138466 | ENA
2024-04-01 | GSE260629 | GEO
2022-04-10 | GSE200423 | GEO
2013-09-24 | E-GEOD-44547 | biostudies-arrayexpress
2018-05-29 | GSE106884 | GEO
2017-01-10 | GSE93303 | GEO
2020-09-21 | GSE146859 | GEO
2016-07-03 | E-GEOD-72096 | biostudies-arrayexpress