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Gene expression profile of neurotoxin exposure in rat midbrain dopaminergic neurons

ABSTRACT: N27 cells are dopaminergic neurons derived from rat midbrain and are extensively employed as a model for neurodegeneration. N27 cells were challenged with 2 neurotoxins associated with Manganism (Manganese Chloride;Mn) and Parkinson's Disease (1-methyl-4-phenylpyridinium ion;MPP+). Mn and MPP+ result in movement dysfunction and are mitochondrial toxins particularly affecting complexes I.This study aimed to understand and differentiate the molecular mechanisms underlying Mn and MPP+ mediated dopaminergic insult by evaluating the differential gene expression pattern in the two models

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE92963 | GEO | 2017/10/04

SECONDARY ACCESSION(S): PRJNA359180

REPOSITORIES: GEO

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Comparative analysis of 1-methyl-4-phenylpyridinium (MPP+) and manganese induced neurotoxic effects on DNA methylation in dopaminergic neurons

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