Proteomics

Dataset Information

0

Protein profiling of 6-OHDA induced PD Model treated by TBN


ABSTRACT: Parkinson's disease (PD) listed as the second most common neurodegenerative disease. 2-[[(1,1-Dimethylethyl)oxidoimino]-methyl]-3,5,6-trimethylpyrazine (TBN), a novel nitrone derivative of tetramethylpyrazine, has shown benefits for the treatment both in vitro and in vivo, TBN protects and rescues dopaminergic neurons from MPP(+) and MPTP/6-OHDA-induced damage by reducing ROS and increasing cellular antioxidative defense capability. Here, we investigate the proteome changes in the 6-OHDA induced PD rat model and the rescue effects after treated by TBN.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

DISEASE(S): Parkinson's Disease

SUBMITTER: Wei Ge  

LAB HEAD: Wei Ge

PROVIDER: PXD004812 | Pride | 2022-03-02

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
MS150814-.msf Msf
MS150814-.pep.xml Pepxml
MS150814-1.raw Raw
MS150814-10.raw Raw
MS150814-11.raw Raw
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