Transcriptomics

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Transcriptional analysis of HD and control iPSCs and derived NPCs


ABSTRACT: Huntington disease (HD) is a dominant neurodegenerative disorder caused by a CAG repeat expansion in HTT. In this study, we corrected HD human induced pluripotent stem cells (hiPSC) using a CRISPR-Cas9 and piggyBac transposon-based approach. To explore transcriptional differences amongst the HD, the corrected lines and the non-related healthy control lines, we performed genome-wide microarray gene expression analysis on the hiPSCs and neural progenitor cells derived from them.

ORGANISM(S): Homo sapiens

PROVIDER: GSE93767 | GEO | 2017/01/19

SECONDARY ACCESSION(S): PRJNA362336

REPOSITORIES: GEO

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