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Identification of nucleolin-targeted RNA transcripts

ABSTRACT: Although Rrp6 contains a helicase and RNase D domain at the C-terminus, it is not involved in stable RNA interactions. We thus hypothesized that mRrp6-mediated nucleolar inflammatory RNA degradation may depend on the pre-mRNA substrate that is delivered to the mRrp6-exosome complex by nucleolin as a guide factor. To demonstrate this possibility, we examined nucleoplasmic RNAs which were bound to nucleolin through RNA-IP-sequencing at the late time points of LPS stimulation.

ORGANISM(S): Mus musculus

PROVIDER: GSE95528 | GEO | 2021/02/28

REPOSITORIES: GEO

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