Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice
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ABSTRACT: We previously demonstrated that transplantation of murine neural stem cells (NSCs) can improve motor and cognitive function in a transgenic model of Dementia with Lewy Bodies (DLB). The underlying neurobiology that mediates such restoration no doubt involves numerous genes acting in concert to modulate signaling within and between host brain cells and transplanted NSCs. In order to identify functionally connected gene networks and additional mechanisms that may contribute to stem cell-induced benefits, we performed weighted gene co-expression network analysis (WGCNA) on striatal tissue isolated from NSC- and vehicle-injected wild-type and DLB mice. WGCNA is proved to be a powerful approach; revealing significant alterations in immune response, neurotransmission, and mitochondria function in response to NSC treatment.
ORGANISM(S): Mus musculus
PROVIDER: GSE95546 | GEO | 2017/03/14
SECONDARY ACCESSION(S): PRJNA377424
REPOSITORIES: GEO
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