Transcriptomics

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Zoledronic acid inhibits NFAT and IL-2 signaling pathways in regulatory T cells and diminishes their suppressive function in patients with metastatic cancer


ABSTRACT: In order to identify the processes altered in T regulatory cells (Treg) by Zoledronic acid (ZA), we examined RNA expression by RNA-seq in Treg treated with and without ZA. We identified gene expression alterations in ZA-treated Treg that were essential to Treg function.

ORGANISM(S): Homo sapiens

PROVIDER: GSE96075 | GEO | 2017/06/26

SECONDARY ACCESSION(S): PRJNA378764

REPOSITORIES: GEO

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