Transcriptomics

Dataset Information

0

Contact-dependent killing by Caulobacter crescentus via cell surface-associated, glycine zipper proteins


ABSTRACT: Most bacteria are in fierce competition with other species for limited nutrients. Some bacteria can kill nearby cells by secreting bacteriocins, a diverse group of proteinaceous antimicrobials. However, bacteriocins are typically freely diffusible, and so of little value to planktonic cells in aqueous environments. Here, we identify an atypical two-protein bacteriocin in the gamma-proteobacterium Caulobacter crescentus that is retained on the surface of producer cells where it mediates cell contact-dependent killing. The bacteriocin-like proteins CdzC and CdzD harbor glycine-zipper motifs, often found in amyloids, and CdzC forms large, insoluble aggregates on the surface of producer cells. These aggregates can drive contact-dependent killing of other organisms, or Caulobacter cells not producing the CdzIE immunity protein. The Cdz system uses a type I secretion system and is unrelated to previously described contact-dependent inhibition systems. However, Cdz-like systems are found in many bacteria, suggesting that this form of contact-dependent inhibition is common.

ORGANISM(S): Caulobacter vibrioides

PROVIDER: GSE96582 | GEO | 2017/05/03

SECONDARY ACCESSION(S): PRJNA379086

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-01-08 | PXD046499 | Pride
2020-12-04 | GSE148401 | GEO
2023-06-30 | E-MTAB-13078 | biostudies-arrayexpress
2021-01-07 | PXD016990 | Pride
| PRJNA379086 | ENA
2023-03-16 | PXD035082 | Pride
2018-12-25 | GSE110750 | GEO
2023-03-16 | PXD035080 | Pride
2018-01-10 | GSE100416 | GEO
2011-04-15 | E-BUGS-110 | biostudies-arrayexpress