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Pro-inflammatory cytokine treatments in primary mouse hepatocytes

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE96770 | GEO | 2017/10/10

SECONDARY ACCESSION(S): PRJNA379601

REPOSITORIES: GEO

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Pro-inflammatory cytokine treatments in primary mouse hepatocytes

Project description:Pro-inflammatory cytokine treatments in primary mouse hepatocytes

| PRJNA379601 | ENA

Characterization of gene expression changes following pro-inflammatory cytokine treatments in primary mouse hepatocytes

Project description:The cytokines interleukin 1β and 6 (IL-1β, IL-6) mediate the systemic acute and chronic inflammatory response. In liver, they both regulate the secretion of acute-phase proteins which curb infection and tissue damage. Using RNA-seq, we show that these cytokines regulate gene transcription in a multifaceted manner to modulate gene expression, leading both to synergistic and antagonistic expression patterns. By mapping changes in enhancer landscape and transcription factor occupancy following cytokine treatment, we show that synergistic gene expression was achieved by cooperation between cytokine-induced transcription factors on the chromatin template. At a subset of enhancers proximal to synergistically-induced acute-phase genes, IL-1β led to enhancer priming and an increase in STAT3 binding. These effects were mediated by NF-κB and were enhancer-specific rather that influencing the entirety of STAT3 binding. Our findings reveal that STAT3-NF-κB crosstalk at the chromatin template plays a major role in transcriptional regulation during inflammation

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Characterization of changes in enhancer activity and transcription factor binding following pro-inflammatory cytokine treatments in primary mouse hepatocytes

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