Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

33 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression Profiles of Primary Mouse Hepatocytes treated with Cyclosporin A and solvent control

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Wim Van den Hof

PROVIDER: E-GEOD-55883 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Expression Profiles of Primary Mouse Hepatocytes treated with Cyclosporin A and solvent control [RNA]

Project description:The transcriptomics changes induced in Primary Mouse Hepatocytes by Cyclosporin A after treatment for 24h and 48h The study investigated differential gene expression in Primary Mouse Hepatocytes mRNA following 24 and 48 hours of exposure to Cyclosporin A and solvent. Three biological replicates per compound/solvent. In total 24 arrays .

2014-07-24 | E-GEOD-55881 | biostudies-arrayexpress

Expression profiles of HepG2 cells treated with low-, high-dose of acetaminophen and solvent control

Project description:The transcriptomics changes induced in the human liver cell line HepG2 by low and high doses of acetaminophen and solvent controls after treatment for 4 time points (12h, 24h, 48h and 72h) The study investigated differential gene expression in HepG2 cell line mRNA following 12 to 72 hours of exposure to low and high doses of acetaminophen and solvent controls. Three biological replicates per compound/solvent.

2015-12-15 | E-GEOD-53216 | biostudies-arrayexpress

Expression Profiles of HepG2 cells treated with 22 compounds and solvent controls

Project description:The transcriptomics changes induced in the human liver cell line HepG2 by 17 hepatotoxic compounds, 5 non-hepatotoxic compounds and solvent controls after treatment for 24h The study investigated differential gene expression in HepG2 cell line mRNA following 24 hours of exposure to 17 hepatotoxic compounds, 5 non-hepatotoxic compounds and solvent controls. Three biological replicates per compound/solvent. In total 105 arrays .

2014-02-14 | E-GEOD-51952 | biostudies-arrayexpress

Expression Profiles of HepG2 cells treated with Cyclosporin A and solvent control

Project description:The transcriptomics changes induced in the human liver cell line HepG2 by Cyclosporin A after treatment for 12h, 24h, 48h and 72h The study investigated differential gene expression in HepG2 cell line mRNA following 12, 24, 48 and 72 hours of exposure to Cyclosporin A and solvent. Three biological replicates per compound/solvent. In total 36 arrays.

2015-01-27 | E-GEOD-45635 | biostudies-arrayexpress

Expression Profiles of mRNAs and microRNAs in HepG2 cells treated with Cyclosporin A and solvent control

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-01-27 | E-GEOD-45802 | biostudies-arrayexpress

Expression Profiles of HepG2 cells treated with following oxidants: 100M-BM-5M menadione, 200M-BM-5M TBH or 50M-BM-5M H2O2

Project description:The transcriptomic changes induced in the human liver cell line HepG2 by 100M-BM-5M menadione, 200M-BM-5M TBH or 50M-BM-5M H2O2 after treatment for 0.5, 1, 2, 4, 6, 8 and 24h. The study investigated differential gene expression in HepG2 cell line mRNA following 0.5, 1, 2, 4, 6, 8 and 24h hours of exposure to 100M-BM-5M menadione, 200M-BM-5M TBH or 50M-BM-5M H2O2 and medium without compound. Three biological replicates per compound/solvent. In total 126 arrays.

2013-05-31 | E-GEOD-39291 | biostudies-arrayexpress

Expression Profiles of HepG2 cells treated with 7M-BM-5M of the genotoxic compound cisplatin

Project description:The transcriptomic changes induced in the human liver cell line HepG2 by 7M-BM-5M of cisplatin after treatment for 12, 24 and 48h The study investigated differential gene expression in HepG2 cell line mRNA following 12,24 and 48 hours of exposure to 7M-BM-5M of cisplatin and its solvent. Three biological replicates per compound/solvent. In total 18 arrays .

2013-12-05 | E-GEOD-38122 | biostudies-arrayexpress

Bortezomib resistance in CCRF-CEM cell line [CGH]

Project description:Bortezomib is a proteasome inhibitor used in severel different hematological malignancies. Resistance to this drug is still poorly understood. In order get more insight in the resistance mechanism, we developed several bortezomib resistant subclones of the CCRF-CEM T-ALL cell line. On these subclones comparative Genome hybridization (arrayCGH) for DNA copy number analysis gene expression and micro-RNA expression arrays were performed. We performed comparative Genome hybridization (arrayCGH) for DNA copy number analysis on four different bortezomib resistant subclones of the CCRF-CEM cell line. The resistant subclones were compared to the parental CCRF-CEM wildtype cell line and reference DNA.

2015-11-04 | E-GEOD-74633 | biostudies-arrayexpress

Expression Profiles of HepG2 cells treated with genotoxic and non-genotoxic agents

Project description:The lack of accurate in vitro assays for predicting in vivo toxicity of chemicals together with new legislations demanding replacement and reduction of animal testing has triggered the development of alternative methods. This study aimed at developing a transcriptomics-based in vitro prediction assay for in vivo genotoxicity. The transcriptomics changes induced in the human liver cell line HepG2 by 34 compounds after treatment for 12h, 24h and 48h were used for the selection of gene-sets that can discriminate between in vivo genotoxins (GTX) and in vivo non-genotoxins (NGTX). By combining publicly available results for these chemicals from standard in vitro genotoxicity studies with transcriptomics, we developed several prediction models. These models were validated by means of an additional set of 28 chemicals. The study investigated differential gene expression in HepG2 cell line mRNA following 12 hours of exposure to 34 different compounds and their solvents; 24 and 48 hours of exposure to 62 different compounds and their solvents. Three biological replicates per compound/solvent. In total 560 arrays .

2012-08-02 | E-GEOD-28878 | biostudies-arrayexpress

Characterization of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows a strong conservation of involved transcription factors

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-12-05 | E-GEOD-38124 | biostudies-arrayexpress