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H4K16ac modification profile difference between Peg3-WT and KO MEF cells

ABSTRACT: PEG3 (Paternally Expressed Gene 3) is an imprinted gene encoding a DNA-binding protein. Two components of the mammalian MSL (Male-Specific Lethal) complex, Msl1 and Msl3, are known to be the genomic targets of PEG3. In this report, we performed genome-wide ChIP-seq experiments profiling H4K16ac levels using a set of MEF cells (Mouse Embryonic Fibroblast), the WT and KO of Peg3. The results indicated that about 10% of the mouse gene catalog showed high levels of H4K16ac levels in Peg3-KO MEFs than in Peg3-WT MEFs. This further suggests that mammalian Peg3 may control its downstream genes through the MSL complex.

ORGANISM(S): Mus musculus

PROVIDER: GSE97459 | GEO | 2017/08/15

SECONDARY ACCESSION(S): PRJNA381884

REPOSITORIES: GEO

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