Direct conversion of mouse fibroblasts into cholangiocyte progenitor cells
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ABSTRACT: We describe that Hnf1α and Foxa3 dramatically facilitate the robust generation of iHepSCs. Notably, the prolonged in vitro culture of Hnf1α and Foxa3 derived iHepSCs induce Notch signaling-mediated secondary conversion into cholangiocyte progenitor-like cells displaying the dramatically enhanced differentiation capacity into the mature cholangiocytes in vitro and in vivo. Our study provides the novel two-step approach for obtaining cholangiocyte progenitor-like cells using defined factors.
ORGANISM(S): Mus musculus
PROVIDER: GSE97507 | GEO | 2018/03/06
REPOSITORIES: GEO
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