Transcriptomic profile of circulating naïve, TCM, TEM and TEMRA T cells in donors from Sri Lanka previously exposed to dengue virus and healthy controls from Sri Lanka [Cohort 1]
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ABSTRACT: Dengue virus is responsible for 400 million human infections each year . The characterization of exact molecular components of immune response associated may help design more effective therapeutic interventions. In this study, we aimed to characterize the immune signature of T cells subtypes associated with previous exposure to dengue virus. Transcriptomic profiling using RNA sequencing was performed on naive, TCM, TEM and TEMRA CD4 T cells isolated from individuals with secondary dengue infections from Sri Lanka, an endemic area, as well as from dengue negative healthy controls.
ORGANISM(S): Homo sapiens
PROVIDER: GSE97861 | GEO | 2017/09/27
SECONDARY ACCESSION(S): PRJNA383117
REPOSITORIES: GEO
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