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Transcriptomic profile of circulating memory T cells in donors previously exposed to dengue virus

ABSTRACT: Dengue virus is responsible for 400 million human infections each year . The characterization of exact molecular components of immune response associated may help design more effective therapeutic interventions. In this study, we aimed to characterize the immune signature of memory T cells associated with previous exposure to dengue virus. Transcriptomic profiling using RNA sequencing was performed on memory CD4 and CD8 T cells isolated from individuals with primary or secondary dengue infections from two endemic areas (Sri Lanka and Nicaragua), as well as from dengue negative healthy controls.

ORGANISM(S): Homo sapiens

PROVIDER: GSE87505 | GEO | 2019/09/29

REPOSITORIES: GEO

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