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Role of JunB in Th17 cell effector stability [RNA-seq]

ABSTRACT: Here we identify the activator protein-1 (AP-1) factor JunB as an essential regulator of Th17 cell identity. JunB activates the expression of Th17 lineage-specifying genes, and coordinately represses genes controlling Th1 and Treg fate. Through regulatory analysis, we find that JunB is a core regulator of global transcriptional programs that promote Th17 cell identity and restrict alternative CD4+ T cell potential.

ORGANISM(S): Mus musculus

PROVIDER: GSE98413 | GEO | 2017/06/17

SECONDARY ACCESSION(S): PRJNA385056

REPOSITORIES: GEO

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Role of JunB in Th17 cell effector stability [ChIP-seq]

Project description:Here we identify the activator protein-1 (AP-1) factor JunB as an essential regulator of Th17 cell identity. JunB activates the expression of Th17 lineage-specifying genes, and coordinately represses genes controlling Th1 and Treg fate. Through regulatory analysis, we find that JunB is a core regulator of global transcriptional programs that promote Th17 cell identity and restrict alternative CD4+ T cell potential.

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Project description:This SuperSeries is composed of the SubSeries listed below.

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