Transcriptomics

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MRNA-seq data from murine colon adenomas and non-adenoma tissues


ABSTRACT: We report that colon adenomas from ApcMin/+ mice not only exhibit similarities in gene expression profile to colon adenomas from azoxymethane / dextran sulfate sodium-treated mice (with activating Ctnnb1 mutations) due to the activation of canonical WNT signaling, but also unique transcriptional changes in the pathways regulating cell cycle progression / proliferation, chromosome segregation / cytoskeletal organization and apoptosis. Subsequent experiments characterized changes in gene expression unique to colon adenomas from ApcMin/+ mice including increases in the H2afv, Map6 and Nsmf transcripts.

ORGANISM(S): Mus musculus

PROVIDER: GSE98496 | GEO | 2017/12/13

SECONDARY ACCESSION(S): PRJNA385269

REPOSITORIES: GEO

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