AP4 regulates stem and Paneth cell homeostasis and promotes adenoma initiation in the intestine (adenoma)
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ABSTRACT: AP4 is frequently expressed in primary CRCs. However, the in vivo relevance of AP4 for development of intestinal tumor formation has not been analyzed by genetic approaches. ApcMin/+ mice with deletion of AP4 were generated and analyzed. The mRNA expression profiles of intestinal adenomas with and without functional AP4 were compared.
ORGANISM(S): Mus musculus
PROVIDER: GSE99437 | GEO | 2018/12/25
REPOSITORIES: GEO
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