Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Menin controls the memory Th2 cell function by maintaining the epigenetic integrity of Th2 cells.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE99261 | GEO | 2017/05/25

SECONDARY ACCESSION(S): PRJNA387752

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Menin controls the memory Th2 cell function by maintaining the epigenetic integrity of Th2 cells. [ChIP-Seq]

Project description:Post-translational modifications of histones are well-established epigenetic modifications that play an important role in gene expression and regulation. These modifications are partly mediated by the Trithorax group (TrxG) complex, which regulates the induction or maintence of gene transcription. We investigated the role of Menin, a component of the TrxG complex, in the acquisition and maintenance of T helper type 2 (Th2) cell identity using T cell-specific Menin-deficient mice. Our gene expression analysis revealed that Menin was involved in the maintenance of the high level expression of the previously identified Th2-specific genes rather than the induction of these genes. This result suggests a role of Menin in the maintenance of Th2 cell identity. Menin directly bound to the Gata3 gene locus, and this Menin-Gata3 axis appeared to form a core unit of the Th2-specific gene regulatory network. Consistent with the phenotype of Menin-deficient Th2 cells observed in vitro, Menin deficiency resulted in the attenuation of effector Th2 cell-induced airway inflammation. In addition, in memory Th2 cells, Menin was found to play an important role in the maintenance of the expression of Th2-specific genes, including Gata3, Il4, and Il13. Consequently, Menin-deficient memory Th2 cells showed an impaired abiliy to recruit eosinophils to the lung, resulting in the attenuation of memory Th2 cell-induced airway inflammation. This study confirmed the critical role of Menin in Th2 cell-mediated immune responses.

2017-05-25 | GSE99259 | GEO

Menin controls the memory Th2 cell function by maintaining the epigenetic integrity of Th2 cells. [RNA-Seq]

2017-05-25 | GSE99260 | GEO

Menin controls the memory Th2 cell function by maintaining the epigenetic integrity of Th2 cells.

Project description:Menin controls the memory Th2 cell function by maintaining the epigenetic integrity of Th2 cells.

| PRJNA387752 | ENA

Vascular integrity is essential for maintaining tissue homeostasis

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-06-01 | GSE162355 | GEO

LATS2 regulates repressive epigenetic integrity via regulation of Polycomb repressive complex 2

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-07-25 | E-GEOD-63538 | biostudies-arrayexpress

NFAT5 Controls the Integrity of Skin

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-12-29 | GSE184180 | GEO

Epigenetic Regulation of Non-canonical Menin Targets Modulates Menin Inhibitor Response in Acute Myeloid Leukemia

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-11-20 | GSE249080 | GEO

DOT1L controls NK cell maturation and lineage integrity

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-04-30 | GSE222235 | GEO

Epigenomic analysis of primary human T cells reveals novel enhancers associated with Th2 memory differentiation and asthma susceptibility

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-07-05 | E-GEOD-53646 | biostudies-arrayexpress

Transcription Factor Foxo1 Controls Memory CD8+ T Cell Responses To Infection

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-05-16 | E-GEOD-46944 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data