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Gene expression changes in white adipose tissue from Ing1- and Gadd45a- single- or double-knockout mice

ABSTRACT: ING1b and GADD45a are nuclear proteins involved in the regulation of cell growth, apoptosis and DNA repair. We previously found that ING1b is essential to target GADD45a-mediated active DNA-demethylation via TET1 to specific loci. Hence, GADD45a and ING1 play a crucial role in epigenetic gene regulation. In order to study the physiological role of ING1-GADD45a on gene expression regulation, we compared the expression profiles of white adipose tissue (WAT) from wildtype, Ing1-/-, Gadd45-/- and double-knockout (DKO) mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE99605 | GEO | 2018/06/11

REPOSITORIES: GEO

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