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Pam3 generates immunosupressive macrophages using p38, MAPK and PTGS2 signaling

ABSTRACT: The gene expression pattern of PAM3 treated monocytes was compared to that of M-CSF, the conventional method of generating immunosuppressive macrophage. Pathways regulated by NF-KB and Akt played a central role in the general process of monocyte to macrophage differentiation. p38 MAPK and PTGS2 signaling biased this process towards the generation of immunosuppressive rather than pro-inflammatory macrophage whereas ERK and JNK were essential for Pam3 but not M-CSF driven maturation

ORGANISM(S): Homo sapiens

PROVIDER: GSE99609 | GEO | 2017/06/03

SECONDARY ACCESSION(S): PRJNA388891

REPOSITORIES: GEO

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