The RhoA guanine nucleotide exchange factor Net1 is required for PyMT mediated mammary gland tumorigenesis and metastasis
Ontology highlight
ABSTRACT: The Net1 RhoGEF has been implicated in invasive behavior in vitro, but its impact on tumorigenesis and metastasis in vivo has not yet been established. We developed Net1 knockout mice and profiled the transcriptomes of the resulting tumors to assess impact on pathway activation.
ORGANISM(S): Mus musculus
PROVIDER: GSE99643 | GEO | 2018/05/23
REPOSITORIES: GEO
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