Transcriptomics

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RNASeq to identify the in vivo mechanism of anti-Ox40 mAb treatment exacerbated lupus in NZB/W F1 Mice


ABSTRACT: We've recently shown that we can accelerate disease in a model of SLE (the NZB/W F1 model) using an anti-Ox40 mAb treatment regimen. The disease acceleration is rapid (within 2 weeks) but its unclear, mechanistically, how OX40 functions to promote disease. To that end we want to perform RNASeq on the sorted OX40-expressing CD4 T cells during treatment to understand how they function in response to OX40 signaling in vivo

ORGANISM(S): Mus musculus

PROVIDER: GSE99646 | GEO | 2017/08/18

SECONDARY ACCESSION(S): PRJNA389204

REPOSITORIES: GEO

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