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The effect of the HDAC inhibitor OSU-HDAC42 on gene expression in esophageal tissues and adenocarcinoma cells II

ABSTRACT: Title: In vitro and in vivo effects of the orally bioavailable phenylbutyrate-derived histone deacetylase inhibitor OSU-HDAC42 on gene expression in esophageal tissues and in esophageal adenocarcinoma cells. Histone deacetylases (HDACs) modulate nucleosomal packaging of DNA, thereby influencing gene transcription and multiple cancer-associated processes. We conducted microarray analysis on esophageal tissue from male Sprague-Dawley rats treated with OSU-HDAC42 or vehicle to assess target effect in an in vivo model utilized for EAC development. Keywords: esophageal tissue from male Sprague-Dawley rats treated with OSU-HDAC42 or vehicle

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE9976 | GEO | 2008/03/20

SECONDARY ACCESSION(S): PRJNA105083

REPOSITORIES: GEO

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Transcription profiling of rat esophageal tissues AND esophageal adenocarcinoma cells treated WITH phenylbutyrate-derived histone deacetylase inhibitor (OSU-HDAC42) OR vehicle TO assess target effect IN an IN vivo MODEL utilized FOR EAC development

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