Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Next-generation sequencing of matched ectopic and eutopic endometrium identifies novel endometriosis-related genes and highlights the role of general metabolism

ABSTRACT: AmpliSeq IonTorrent sequencing of mRNA derived from ectopic lesions and matched eutopic endometrium. There were 4 matched pairs overall; all donors were in mid-secretory phase. [SUBMITTER_CITATION]: A. V. Predeus, E. S. Vashukova, A. S. Glotov, M. M. Danilova, N. S. Osinovskaya, O. V. Malysheva, N. Yu. Shved, N. Ganbarli, M. I. Yarmolinskaya, T. E. Ivashchenko, V. S. Baranov - Next-Generation Sequencing of Matched Ectopic and Eutopic Endometrium Identifies Novel Endometriosis-Related Genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE99949 | GEO | 2018/03/21

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis

Project description:Endometriosis is defined as the presence of endometrial tissue (eutopic tissue) outside the uterus (ectopic tissue). We assessed differentially expressed microRNAs in ectopic endometrium compared with eutopic endometrium. Comparison of paired eutopic/ectopic endometrium microRNAs from three patients.

2010-12-30 | E-GEOD-26346 | biostudies-arrayexpress

Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis

2010-12-30 | GSE26346 | GEO

Transcriptomic changes in eutopic endometrium and ectopic lesions in mouse model during progression of endometriosis-related infertility

Project description:In this study, we performed transcriptomic analysis in ectopic lesions and eutopic endometrial tissues from both fertile and subfertile mice with endometriosis. We identified the positive correlation of the gene signatures between the mouse and human in ectopic lesions. Conserved gene networks were activated in all the ectopic lesions including estradiol, immune, fibrosis, and angiogenesis pathways. The interactions mediated through hormone, cytokine, and growth factor as well as their corresponding receptors were predicted between the ectopic and eutopic endometrium. EGF and WNT signaling were more suppressed in the eutopic endometrium from subfertile mice. Our results revealed that our mouse endometriosis model recapitulates the important transcriptomic changes of endometriosis progression in human ectopic lesions including the essential regulator network and intensive inter-communications between ectopic and eutopic endometrium. Our preclinical animal model for endometriosis will be invaluable to understand etiology and pathophysiology on endometriosis.

2024-05-29 | GSE240392 | GEO

Macrophages in eutopic endometrium endometriosis

Project description:Comparison of macrophages M1 (M1) and M2 (M2) from eutopic endometrium from women with and without endometriosis

2020-01-22 | GSE130435 | GEO

The differential expression of tRF&tiRNA in eutopic and ectopic endometrial tissue of patients with ovarian endometriosis.

Project description:Endometriosis is a chronic gynecological disease that afflicts millions of women of reproductive age and has traditionally been diagnosed by laparoscopic surgery. This diagnostic barrier delays identification and treatment by years, resulting in prolonged pain and disease progression. Development of a noninvasive diagnostic test could significantly improve timely disease detection. We characterized eutopic and ectopic endometrium from five patients with ovarian endometriosis using tRF&tiRNA sequencing. We identified 294 tsRNAs by RNA microarray technique in eutopic and ectopic endometrium. Under the criteria of |log2FoldChange >2.0| and p-value < 0.05, 11 tRFs/tiRNAs were reported to be dysregulated in ectopic endometrial tissue compared with eutopic endometrial tissue, of which eight were up-regulated, and three were down-regulated.

2023-10-30 | GSE246202 | GEO

The differential expression of mRNAs and long noncoding RNAs between ectopic and eutopic endometrium of adenomyosis

Project description:Adenomyosis, defined as ectopic endometrial tissue within the myometrium, can often be misdiagnosed as multiple uterine leiomyomata or endometrial thickening. We therefore performed a combined mRNA and long noncoding (lnc)RNA microarray and bioinformatic analysis of eutopic and ectopic endometrium in women with adenomyosis to better understand its pathogenesis and help in the development of a semi-invasive diagnostic test. A total of 586 mRNAs were increased and 305 mRNAs decreased in ectopic endometrium of adenomyosis compared with eutopic endometrium, while 388 lncRNA transcripts were up-regulated and 188 down-regulated in ectopic compared with paired eutopic endometrial tissue. Bioinformatic analysis suggested a series of metabolic and molecular abnormalities in adenomyosis, which have many similarities with endometriosis. Furthermore, our study constitutes the first known report of lncRNA expression patterns in human adenomyosis ectopic and eutopic endometrial tissue. Two-condition experiment, ectopic endometrium vs. eutopic endometrium. 3 samples,self-control

2015-10-28 | E-GEOD-74373 | biostudies-arrayexpress

Macrophages in eutopic endometrium endometriosis

Project description:Macrophages in eutopic endometrium endometriosis

| PRJNA540256 | ENA

Proteomic profiling of eutopic endometrium from females with endometriosis compared to healthy controls

Project description:The aim of the present study was to study the proteomic profile of eutopic endometrium from patients with endometriosis vs. healthy controls

2019-01-09 | PXD009090 | Pride

Transcriptional profiling of healthy, eutopic and ectopic endometrial organoids

Project description:We performed RNA-seq on RNA samples of organoids derived from healthy, eutopic (endometrium of patients with endometriosis) and ectopic (endometriosis) endometrium

2019-06-05 | GSE118928 | GEO

Genome-wide DNA methylation profiling in cultured eutopic and ectopic endometrial stromal cells (expression)

Project description:Transcriptome profiles were investigated in isolated endometrial stromal cells (ESCs) from eutopic and ectopic endometrium. The profiles were quite different between eutopic ESC and ectopic ESC, whereas no clear dfference was recognized between eutopic ESC with and without endometriosis.

2013-09-07 | GSE47360 | GEO