Metabolomics

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GNPS - MS/MS networking guided analysis of molecule and gene cluster families - Figure 1


ABSTRACT: Paper Title: MS/MS networking guided analysis of molecule and gene cluster families Author List: Don Duy Nguyen, Cheng-Hsuan Wu, Wilna J. Moree, Anne Lamsa, Marnix H. Medema, Xiling Zhao, Ronnie G. Gavilan, Marystella Aparicio, Librada Atencio, Chanaye Jackson, Javier Ballesteros, Joel Sanchez, Jeramie D. Watrous, Vanessa V. Phelan, Corine van de Wiel, Roland D. Kersten, Samina Mehnaz, René De Mot, Elizabeth A. Shank, Pep Charusanti, Harish Nagarajan, Brendan M. Duggan, Bradley S. Moore, Nuno Bandeira, Bernhard Ø. Palsson, Kit Pogliano, Marcelino Gutiérrez, and Pieter C. Dorrestein Citation: Proc. Natl. Acad. Sci USA 2013 110(28):E2611-2620. doi: 10.1073/pnas.1303471110 PubMedID: 23798442 Brief description of the data submitted: RAW files used to generate Figure 1. Bacterial network of 42 strains of bacilli and 18 strains of pseudomonads with a cosine similarity score cutoff of 0.70. This network was generated using nanoDESI-MS/MS.

INSTRUMENT(S): LTQ FT

ORGANISM(S): Bacillus Es382 Bacillus Es341 Bacillus Es221 Bacillus Es342 Bacillus Es386 Bacillus Es222 Bacillus Es343 Bacillus Es387 Bacillus Es223 Bacillus Gp24 Bacillus Ls18 Bacillus Es345 Bacillus Gp25 Bacillus Es20 Bacillus Zk4636 Pseudomonas Ch36 Bacillus Zk4678 Bacillus Zk4633 Pseudomonas Rw10s2 Pseudomonas Rw10s1 Bacillus Es190 Bacillus Fzb42 Pseudomonas Putdia Pseudomonas 3w11m1 Bacillus Es332 Bacillus Es333 Bacillus Es335 Bacillus Es336 Bacillus Es337 Pseudomonas Es60 Pseudomonas C52 Bacillus Subtilis 3610 Bacillus Es120 Pseudomonas Hcl17 Pseudomonas Es11 Bacillus Es44 Pseudomonas Es97 Bacillus Py79 Bacillus Ls276 Bacillus Lcts Bacillus Qbm1551 Pseudomonas Aurantiaca Pseudomonas Bw10s1 Pseudomonas Pa14 Bacillus Es392 Pseudomonas Rw951 Bacillus Es73 Bacillus Es113 Bacillus Ls29 Bacillus Es114 Bacillus Ls28 Bacillus Es115 Bacillus Es76 Bacillus Kp1032 Bacillus Es118 Pseudomonas Pa01 Bacillus Lct22 Pseudomonas Bw11p2

SUBMITTER: Pieter Dorrestein 

PROVIDER: MSV000078552 | GNPS | Tue Feb 18 17:26:00 GMT 2014

REPOSITORIES: GNPS

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The ability to correlate the production of specialized metabolites to the genetic capacity of the organism that produces such molecules has become an invaluable tool in aiding the discovery of biotechnologically applicable molecules. Here, we accomplish this task by matching molecular families with gene cluster families, making these correlations to 60 microbes at one time instead of connecting one molecule to one organism at a time, such as how it is traditionally done. We can correlate these f  ...[more]

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