GNPS-In vitro reaction of CYP450 Bmp7 with 2,4-dibromophenol substrate
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Agilent 6530 Accurate Mass Q-TOF
ORGANISM(S): In Vitro Reaction Of Cyp450 Bmp7 With 2,4-dibromophenol Substrate
SUBMITTER: Bradley S Moore
PROVIDER: MSV000078925 | GNPS | Wed Nov 05 16:48:00 GMT 2014
REPOSITORIES: GNPS
Publications
Enzymatic synthesis of polybrominated dioxins from the marine environment.
Agarwal Vinayak V Moore Bradley S BS
ACS chemical biology 20140728 9
Polyhalogenated dibenzo-p-dioxins are arguably among the most toxic molecules known to man. In addition to anthropogenic sources, marine invertebrates also harbor polybrominated dibenzo-p-dioxins of as yet unknown biogenic origin. Here, we report that the bmp gene locus in marine bacteria, a recently characterized source of polybrominated diphenyl ethers, can also synthesize dibenzo-p-dioxins by employing different phenolic initiator molecules. Our findings also diversify the structural classes ...[more]
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