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GNPS - Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora

ABSTRACT: Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora

INSTRUMENT(S): 6520A Quadrupole Time-of-Flight LC/MS

ORGANISM(S): Salinispora (ncbitaxon:168694)

SUBMITTER: Paul R Jensen / Katherine R. Duncan

PROVIDER: MSV000079484 | GNPS | Wed Jan 27 00:59:00 GMT 2016

REPOSITORIES: GNPS

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Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species.

Duncan Katherine R KR Crüsemann Max M Lechner Anna A Sarkar Anindita A Li Jie J Ziemert Nadine N Wang Mingxun M Bandeira Nuno N Moore Bradley S BS Dorrestein Pieter C PC Jensen Paul R PR

Chemistry & biology 20150409 4

Genome sequencing has revealed that bacteria contain many more biosynthetic gene clusters than predicted based on the number of secondary metabolites discovered to date. While this biosynthetic reservoir has fostered interest in new tools for natural product discovery, there remains a gap between gene cluster detection and compound discovery. Here we apply molecular networking and the new concept of pattern-based genome mining to 35 Salinispora strains, including 30 for which draft genome sequen ...[more]

PMID: 25865308

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